Dynamic Light Scattering (DLS)

Dynamic light scattering (DLS) is an indirect, high-throughput method for measuring the sizes – by hydrodynamic diameter (HDD) – of particles in a solution.
Strengths
- Fast, automated analysis = rapid results
- Accepts low sample concentrations
- Provides overall particle size distribution
- Works well with a wide range of particle sizes
- Nondestructive analysis
Limitations
- Does not provide particle shape information for irregular geometries
- Heavy particles can sometimes sediment, causing artifacts
- Bigger particles are higher-weighted in the raw intensity distribution