Inductively Coupled Plasma Mass Spectroscopy (ICPMS)

Inductively Coupled Plasma Mass Spectroscopy
High resolution mass spectrum captured on a 1 ppb tune solution in the mass range 105 to 155 amu

Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) is a destructive chemical analysis technique which measures the elemental composition of a sample. It is one of the most sensitive multiple-element analysis methods, with detection limits down to ng/L.

Strengths
  • Extremely high elemental sensitivity: limit on the order of parts-per-trillion
  • Can detect most elements in the periodic table with a single experiment
  • Accepts a wide array of sample types (solution or solid, inorganic or organic, simple composition to complex mixtures)
  • Rapid analysis
  • Isotope detection
Limitations
  • Quantitative analysis requires parallel measurement on reference / control sample
  • Does not easily capture molecular / compound information
  • Destructive
  • Sample preparation such as sample digestion via acid can be time-consuming
  • Limited total dissolved solids (TDS) tolerance
Base Prices
Technique Variants
Pricing Starts At
Action
Inductively Coupled Plasma Mass Spectroscopy (ICPMS)
Please contact us
Laser Ablation Inductively Coupled Plasma Mass Spectroscopy (LA-ICP-MS)

Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA ICP MS) enables sensitive elemental and isotopic analysis on a wide variety of solid samples to detection limits of 10’s of parts-per-billion.

Learn More  
Please contact us
LA-ICPMS: Linescan (LA-ICP-MS)
Please contact us
LA-ICPMS: 2D Map (LA-ICP-MS)
Please contact us
LA-ICPMS: Depth Profile (LA-ICP-MS)
Please contact us
Example Outputs

High resolution mass spectrum captured on a 1 ppb tune solution in the mass range 105 to 155 amu

From: Thermo Fisher Scientific Technical Note

Calibration curve generated for 175Lu quantification in a standard / control sample. The plot shown is in log scale from 1pg∙L-1 to 5 mg∙L-1. The background of the blank was <0.3 cps, with over 10 orders of magnitude dynamic calibration range to 5 mg∙L-1 at 8.57 Gcps with an excellent correlation coefficient of R2=1.000

From: Thermo Fisher Scientific Technical Note
Instruments Used for ICPMS
Thermo Scientific iCAP TQ ICP-MS

Thermo Scientific iCAP TQ ICP-MS

  • Detection Limits vary by atomic species: as low as < 0.5 (ng/L)b (for 9Be)
  • Abundance Sensitivity: < 0.005 ppm
  • Minimum Dwell Time: 100 μs in pulse and analog
  • Dynamic Range: more than 10 orders of magnitude
  • Stability: below 2.0 %RSD over 10 minutes
  • Isotopic Ratio Precision: below 0.1 %RSD
  • Nebulizer: Concentric glass
  • Nebulizer Default Flow Rate: 400 uL/min (pumped)
  • View Instrument Spec Sheet
Sample Requirements
  • Liquid, aqueous phase
  • We can take a solid-state sample and digest it for ICP-MS as well
  • Additional requirements depend on instrument specs
How ICPMS Works

In a standard ICP-MS, an inert gas (argon) is inductively heated via current through a surrounding electromagnetic coil to form a plasma.

The sample (typically in liquid form) is inserted, aerosolized, and digested in the plasma into ion fragments, which are accelerated through a quadrupole mass analyzer to yield a mass spectrum.

Peaks in this spectrum correspond to the elemental ions present in the original sample, yielding quantitative and semi-quantitative elemental composition information.

Comparison link sent successfully
Please use valid email address
You need to have at least 2 techniques to compare
You can select maximum 5 techniques
Covalent uses cookies to improve your browsing experience and to help you access the most relevant information and services efficiently. To learn more, view our
Decline
I Accept Cookies
techniques selected
Select at least 2 techniques to compare Compare techniques